{ "id": "coreg", "recordTier": "source_traceable_archive", "editorial": { "reviewedAt": "2026-08-21", "status": "published_traceable_archive" }, "names": { "brand": "Coreg", "generic": "卡维地洛", "aliases": [ "COREG", "carvedilol" ], "marketBrandNames": [], "mainlandChinaTradeNameCue": null }, "identity": { "therapeuticArea": "心血管", "sourceArchiveMarket": "美国当前 COREG 卡维地洛公开标签（DailyMed 页面 2026-07-31 更新；SPL v3 于 2026-08-03 发布）", "dosageFormClass": "普通口服薄膜衣片：3.125 mg、6.25 mg、12.5 mg、25 mg；不与 COREG CR 缓释胶囊混同", "dosageFormClassCode": "oral_modified_release", "route": "口服", "routeCode": "oral", "historicalApprovalEntry": "1995（当前美国标签所列 Initial U.S. Approval）", "archiveSponsorText": "Waylis Therapeutics LLC / DailyMed（NLM）当前美国公开标签" }, "matchPolicy": { "contract": "reviewed_name_and_exclusion_cues_v1", "exactMatchNames": [], "excludedProductCues": [ "COREG CR", "carvedilol phosphate", "extended-release", "缓释胶囊", "卡维地洛磷酸盐" ], "exclusionPrecedence": "before_name_candidate" }, "productPresentations": [ { "id": "us-coreg-carvedilol-tablet-3-125mg-100-count-bottle-ndc-80725-139-20", "marketCode": "US", "labelVersion": { "zh": "DailyMed 页面 2026-07-31 更新；SPL v3 于 2026-08-03 发布", "en": "DailyMed page updated 31 Jul 2026; SPL v3 published 3 Aug 2026" }, "dosageForm": { "zh": "COREG 卡维地洛普通口服薄膜衣片", "en": "COREG carvedilol immediate-release oral film-coated tablet" }, "route": { "zh": "口服", "en": "oral" }, "routeCodes": [ "oral" ], "productCode": "NDC 80725-139-20", "pouchCode": null, "applicationNumber": null, "presentationRole": null, "primaryStrengthBasisCode": "per_tablet", "primaryDisplay": { "zh": "每片卡维地洛 3.125 mg；100 片瓶装", "en": "Carvedilol 3.125 mg per tablet; 100-tablet bottle" }, "imageUrl": "https://dailymed.nlm.nih.gov/dailymed/image.cfm?setid=07c619c6-4a0c-445e-94fa-664a54f68a39&name=coreg-06.jpg", "visualStatus": "exact_public_label_package_image", "labeledQuantities": [ { "ingredient": { "zh": "卡维地洛", "en": "carvedilol" }, "value": 3.125, "unit": "mg", "basisCode": "per_tablet", "basisLabel": { "zh": "每片标示量；不是个人片数、加减量、分片或换药规则", "en": "labelled amount per tablet; not an individual tablet-count, adjustment, splitting or switching rule" } } ], "concentration": null, "container": { "typeCode": "bottle", "typeLabel": { "zh": "瓶装", "en": "bottle" }, "fill": null, "countPerPackage": 100, "countUnit": { "zh": "片/瓶", "en": "tablets per bottle" } }, "deliveryDevice": null, "compatibleReusableDevice": null, "listingStatus": null, "package": { "count": 100, "unit": { "zh": "片/瓶", "en": "tablets per bottle" } }, "physicalClues": { "color": { "zh": "橙色标示条", "en": "orange strength band" }, "shape": { "zh": "白色椭圆形薄膜衣片", "en": "white oval film-coated tablet" }, "imprint": "39 / WP", "scoreStatus": "not_scored", "patchAreaCm2": null }, "comparisonNotice": null, "source": { "id": "src_7a6d051d5bf5e431", "label": "DailyMed（NLM）：COREG 卡维地洛当前美国公开标签（Waylis Therapeutics；SPL v3，2026-08-03 发布）", "url": "https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=07c619c6-4a0c-445e-94fa-664a54f68a39", "audience": "public", "reviewStatus": "approved", "publish": true, "documentStatus": "current_regulatory_record", "documentKind": "product_label", "market": "US", "accessStatus": "public_access_confirmed", "accessMode": "public_web_page", "accessVerifiedAt": "2026-08-20", "reviewedAt": "2026-08-20" }, "scope": "package_and_label_identity_only_not_personal_dosing_or_conversion" }, { "id": "us-coreg-carvedilol-tablet-6-25mg-100-count-bottle-ndc-80725-140-20", "marketCode": "US", "labelVersion": { "zh": "DailyMed 页面 2026-07-31 更新；SPL v3 于 2026-08-03 发布", "en": "DailyMed page updated 31 Jul 2026; SPL v3 published 3 Aug 2026" }, "dosageForm": { "zh": "COREG 卡维地洛普通口服薄膜衣片", "en": "COREG carvedilol immediate-release oral film-coated tablet" }, "route": { "zh": "口服", "en": "oral" }, "routeCodes": [ "oral" ], "productCode": "NDC 80725-140-20", "pouchCode": null, "applicationNumber": null, "presentationRole": null, "primaryStrengthBasisCode": "per_tablet", "primaryDisplay": { "zh": "每片卡维地洛 6.25 mg；100 片瓶装", "en": "Carvedilol 6.25 mg per tablet; 100-tablet bottle" }, "imageUrl": "https://dailymed.nlm.nih.gov/dailymed/image.cfm?setid=07c619c6-4a0c-445e-94fa-664a54f68a39&name=coreg-07.jpg", "visualStatus": "exact_public_label_package_image", "labeledQuantities": [ { "ingredient": { "zh": "卡维地洛", "en": "carvedilol" }, "value": 6.25, "unit": "mg", "basisCode": "per_tablet", "basisLabel": { "zh": "每片标示量；不是个人片数、加减量、分片或换药规则", "en": "labelled amount per tablet; not an individual tablet-count, adjustment, splitting or switching rule" } } ], "concentration": null, "container": { "typeCode": "bottle", "typeLabel": { "zh": "瓶装", "en": "bottle" }, "fill": null, "countPerPackage": 100, "countUnit": { "zh": "片/瓶", "en": "tablets per bottle" } }, "deliveryDevice": null, "compatibleReusableDevice": null, "listingStatus": null, "package": { "count": 100, "unit": { "zh": "片/瓶", "en": "tablets per bottle" } }, "physicalClues": { "color": { "zh": "绿色标示条", "en": "green strength band" }, "shape": { "zh": "白色椭圆形薄膜衣片", "en": "white oval film-coated tablet" }, "imprint": "4140 / WP", "scoreStatus": "scored_status_not_a_split_instruction", "patchAreaCm2": null }, "comparisonNotice": null, "source": { "id": "src_7a6d051d5bf5e431", "label": "DailyMed（NLM）：COREG 卡维地洛当前美国公开标签（Waylis Therapeutics；SPL v3，2026-08-03 发布）", "url": "https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=07c619c6-4a0c-445e-94fa-664a54f68a39", "audience": "public", "reviewStatus": "approved", "publish": true, "documentStatus": "current_regulatory_record", "documentKind": "product_label", "market": "US", "accessStatus": "public_access_confirmed", "accessMode": "public_web_page", "accessVerifiedAt": "2026-08-20", "reviewedAt": "2026-08-20" }, "scope": "package_and_label_identity_only_not_personal_dosing_or_conversion" }, { "id": "us-coreg-carvedilol-tablet-12-5mg-100-count-bottle-ndc-80725-141-20", "marketCode": "US", "labelVersion": { "zh": "DailyMed 页面 2026-07-31 更新；SPL v3 于 2026-08-03 发布", "en": "DailyMed page updated 31 Jul 2026; SPL v3 published 3 Aug 2026" }, "dosageForm": { "zh": "COREG 卡维地洛普通口服薄膜衣片", "en": "COREG carvedilol immediate-release oral film-coated tablet" }, "route": { "zh": "口服", "en": "oral" }, "routeCodes": [ "oral" ], "productCode": "NDC 80725-141-20", "pouchCode": null, "applicationNumber": null, "presentationRole": null, "primaryStrengthBasisCode": "per_tablet", "primaryDisplay": { "zh": "每片卡维地洛 12.5 mg；100 片瓶装", "en": "Carvedilol 12.5 mg per tablet; 100-tablet bottle" }, "imageUrl": "https://dailymed.nlm.nih.gov/dailymed/image.cfm?setid=07c619c6-4a0c-445e-94fa-664a54f68a39&name=coreg-08.jpg", "visualStatus": "exact_public_label_package_image", "labeledQuantities": [ { "ingredient": { "zh": "卡维地洛", "en": "carvedilol" }, "value": 12.5, "unit": "mg", "basisCode": "per_tablet", "basisLabel": { "zh": "每片标示量；不是个人片数、加减量、分片或换药规则", "en": "labelled amount per tablet; not an individual tablet-count, adjustment, splitting or switching rule" } } ], "concentration": null, "container": { "typeCode": "bottle", "typeLabel": { "zh": "瓶装", "en": "bottle" }, "fill": null, "countPerPackage": 100, "countUnit": { "zh": "片/瓶", "en": "tablets per bottle" } }, "deliveryDevice": null, "compatibleReusableDevice": null, "listingStatus": null, "package": { "count": 100, "unit": { "zh": "片/瓶", "en": "tablets per bottle" } }, "physicalClues": { "color": { "zh": "红色标示条", "en": "red strength band" }, "shape": { "zh": "白色椭圆形薄膜衣片", "en": "white oval film-coated tablet" }, "imprint": "4141 / WP", "scoreStatus": "scored_status_not_a_split_instruction", "patchAreaCm2": null }, "comparisonNotice": null, "source": { "id": "src_7a6d051d5bf5e431", "label": "DailyMed（NLM）：COREG 卡维地洛当前美国公开标签（Waylis Therapeutics；SPL v3，2026-08-03 发布）", "url": "https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=07c619c6-4a0c-445e-94fa-664a54f68a39", "audience": "public", "reviewStatus": "approved", "publish": true, "documentStatus": "current_regulatory_record", "documentKind": "product_label", "market": "US", "accessStatus": "public_access_confirmed", "accessMode": "public_web_page", "accessVerifiedAt": "2026-08-20", "reviewedAt": "2026-08-20" }, "scope": "package_and_label_identity_only_not_personal_dosing_or_conversion" }, { "id": "us-coreg-carvedilol-tablet-25mg-100-count-bottle-ndc-80725-142-20", "marketCode": "US", "labelVersion": { "zh": "DailyMed 页面 2026-07-31 更新；SPL v3 于 2026-08-03 发布", "en": "DailyMed page updated 31 Jul 2026; SPL v3 published 3 Aug 2026" }, "dosageForm": { "zh": "COREG 卡维地洛普通口服薄膜衣片", "en": "COREG carvedilol immediate-release oral film-coated tablet" }, "route": { "zh": "口服", "en": "oral" }, "routeCodes": [ "oral" ], "productCode": "NDC 80725-142-20", "pouchCode": null, "applicationNumber": null, "presentationRole": null, "primaryStrengthBasisCode": "per_tablet", "primaryDisplay": { "zh": "每片卡维地洛 25 mg；100 片瓶装", "en": "Carvedilol 25 mg per tablet; 100-tablet bottle" }, "imageUrl": "https://dailymed.nlm.nih.gov/dailymed/image.cfm?setid=07c619c6-4a0c-445e-94fa-664a54f68a39&name=coreg-09.jpg", "visualStatus": "exact_public_label_package_image", "labeledQuantities": [ { "ingredient": { "zh": "卡维地洛", "en": "carvedilol" }, "value": 25, "unit": "mg", "basisCode": "per_tablet", "basisLabel": { "zh": "每片标示量；不是个人片数、加减量、分片或换药规则", "en": "labelled amount per tablet; not an individual tablet-count, adjustment, splitting or switching rule" } } ], "concentration": null, "container": { "typeCode": "bottle", "typeLabel": { "zh": "瓶装", "en": "bottle" }, "fill": null, "countPerPackage": 100, "countUnit": { "zh": "片/瓶", "en": "tablets per bottle" } }, "deliveryDevice": null, "compatibleReusableDevice": null, "listingStatus": null, "package": { "count": 100, "unit": { "zh": "片/瓶", "en": "tablets per bottle" } }, "physicalClues": { "color": { "zh": "紫色标示条", "en": "purple strength band" }, "shape": { "zh": "白色椭圆形薄膜衣片", "en": "white oval film-coated tablet" }, "imprint": "4142 / WP", "scoreStatus": "scored_status_not_a_split_instruction", "patchAreaCm2": null }, "comparisonNotice": null, "source": { "id": "src_7a6d051d5bf5e431", "label": "DailyMed（NLM）：COREG 卡维地洛当前美国公开标签（Waylis Therapeutics；SPL v3，2026-08-03 发布）", "url": "https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=07c619c6-4a0c-445e-94fa-664a54f68a39", "audience": "public", "reviewStatus": "approved", "publish": true, "documentStatus": "current_regulatory_record", "documentKind": "product_label", "market": "US", "accessStatus": "public_access_confirmed", "accessMode": "public_web_page", "accessVerifiedAt": "2026-08-20", "reviewedAt": "2026-08-20" }, "scope": "package_and_label_identity_only_not_personal_dosing_or_conversion" } ], "comparisonPresentations": [], "appearanceReferences": [], "visualReference": { "presentationId": "us-coreg-carvedilol-tablet-12-5mg-100-count-bottle-ndc-80725-141-20", "status": "historical_public_label_image_not_product_authentication", "imageUrl": "https://dailymed.nlm.nih.gov/dailymed/image.cfm?setid=07c619c6-4a0c-445e-94fa-664a54f68a39&name=coreg-08.jpg", "alt": "COREG 卡维地洛在美国 DailyMed 当前公开标签中的 12.5 mg、NDC 80725-141-20、100 片瓶装展示面", "archiveMarket": "美国", "labelVersion": "DailyMed 页面 2026-07-31 更新；SPL v3 于 2026-08-03 发布", "presentation": "COREG 卡维地洛：每片 12.5 mg，NDC 80725-141-20，100 片瓶装展示面。", "notice": "此图只对应美国 DailyMed 当前标签中的 COREG、卡维地洛 12.5 mg、NDC 80725-141-20 与 100 片瓶装。它只帮助核对品牌、通用名、每片标示量、普通口服片、包装数量与来源；不用于鉴定真伪，也不证明其他强度、COREG CR 缓释胶囊、其他包装、其他市场、实际可得性、原研身份、可替代性或任何个人的片数、掰开、停用、联用或换药方案。", "source": { "id": "src_7a6d051d5bf5e431", "label": "DailyMed（NLM）：COREG 卡维地洛当前美国公开标签（Waylis Therapeutics；SPL v3，2026-08-03 发布）", "url": "https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=07c619c6-4a0c-445e-94fa-664a54f68a39", "audience": "public", "reviewStatus": "approved", "publish": true, "documentStatus": "current_regulatory_record", "documentKind": "product_label", "market": "US", "accessStatus": "public_access_confirmed", "accessMode": "public_web_page", "accessVerifiedAt": "2026-08-20", "reviewedAt": "2026-08-20" } }, "visualCoverageNote": null, "labelReading": { "coverage": "drug_specific_source_review", "title": { "zh": "COREG 说明书放大阅读：四种 mg 是不同普通片剂身份，不是自行加减的阶梯", "en": "COREG label reading: four mg values identify distinct regular tablets, not a self-adjustment ladder" }, "summary": { "zh": "本模块以美国 DailyMed 当前公开标签为阅读入口，帮助核对 COREG、卡维地洛、每片 3.125/6.25/12.5/25 mg、普通口服片、准确 NDC 和 100 片瓶装。它不决定个人片数、何时开始或停用、能否掰开、何时与另一种心血管产品同用，或怎样从 COREG CR 转换。", "en": "This module uses the current U.S. DailyMed public label to check COREG, carvedilol, 3.125/6.25/12.5/25 mg per tablet, regular oral-tablet form, exact NDC and 100-tablet bottle. It does not decide an individual's tablet count, when to start or stop, whether to split, use with another cardiovascular product, or how to change from COREG CR." }, "checks": [ { "zh": "先把 COREG、卡维地洛、每片 mg、普通口服片、实际 NDC、瓶装数量和目标市场一起核对。毫克数只描述这一准确片剂每片的标示量，不是网页可以换算成个人片数、加减量或由一盒换到另一盒的规则。", "en": "Check COREG, carvedilol, mg per tablet, regular oral-tablet form, actual NDC, bottle count and target market together. Milligrams describe the labelled amount in an exact tablet, not a web rule for personal tablet count, adjustment or replacing one pack with another." }, { "zh": "COREG CR 是缓释胶囊，标签所示成分形式和剂型与本页普通片不同。不要依据同一品牌、相近数字或“每天一次/两次”的说法自行换算、叠加、错开、轮换或替换；带准确药盒和完整药单请药师或开方团队核对。", "en": "COREG CR is an extended-release capsule with a different dosage form and labelled ingredient form from the regular tablets on this page. Do not self-convert, combine, separate, alternate or substitute based on a shared brand, similar numbers or a claim about frequency; have the exact packs and full medicine list reviewed by a pharmacist or prescriber." }, { "zh": "当前标签对突然停用、心率变慢、低血压、心衰/液体潴留、糖尿病低血糖症状掩盖以及与地高辛、胺碘酮、维拉帕米/地尔硫卓类、降压药和降糖药等联用列有需要核对的线索。它们不是网页可以据此决定“能不能一起吃、谁先停或怎么错开”的答案。", "en": "The current label flags abrupt discontinuation, slow heart rate, low blood pressure, heart failure/fluid retention, masking of low-glucose symptoms in diabetes, and review cues with digoxin, amiodarone, verapamil/diltiazem-type products, blood-pressure medicines and glucose-lowering medicines. These do not let a webpage decide whether products can be used together, which to stop first or how to separate them." }, { "zh": "出现昏厥、显著头晕、胸痛、呼吸困难、心率明显异常、体重或水肿快速变化、意识改变或其他急性严重不适时，应优先使用当地紧急医疗支持；不要等待网页检索，也不要自行骤停或靠另一盒心血管药抵消。", "en": "With fainting, marked dizziness, chest pain, breathing difficulty, a clearly abnormal heart rate, rapid change in weight or swelling, altered consciousness or another acute severe problem, prioritise local urgent medical support; do not wait for a website search, abruptly self-stop, or try to counteract it with another cardiovascular pack." } ], "source": { "id": "src_7a6d051d5bf5e431", "label": "DailyMed（NLM）：COREG 卡维地洛当前美国公开标签（Waylis Therapeutics；Warnings, Interactions and Patient Counseling）", "url": "https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=07c619c6-4a0c-445e-94fa-664a54f68a39", "audience": "public", "reviewStatus": "approved", "publish": true, "documentStatus": "current_regulatory_record", "documentKind": "product_label", "market": "US", "accessStatus": "public_access_confirmed", "accessMode": "public_web_page", "accessVerifiedAt": "2026-08-20", "reviewedAt": "2026-08-20" }, "scope": "label_literacy_only_no_individual_dosing_or_substitution" }, "mechanismReading": { "title": { "zh": "卡维地洛怎样起作用：它具有 α1 与 β 肾上腺素能阻断作用", "en": "How carvedilol works: it has alpha-1 and beta-adrenergic blocking activity" }, "summary": { "zh": "美国 COREG 标签将卡维地洛描述为具有 α1 阻断和非选择性 β 肾上腺素能阻断活性的药物。这个机制帮助理解为何心率、血压、心脏功能、呼吸状况、糖尿病和完整药单需要一起核对；它不预测个人疗效、耐受性、片数、是否适合、是否需要基因检测或与任何其他药的联用方案。", "en": "The U.S. COREG label describes carvedilol as having alpha-1 blocking and nonselective beta-adrenergic blocking activity. This helps explain why heart rate, blood pressure, cardiac function, respiratory status, diabetes and the complete medicine list need joint review; it does not predict individual benefit, tolerance, tablet count, suitability, need for genetic testing or a plan to combine with another medicine." }, "checks": [ { "zh": "“α/β 阻断”是作用路径，不是从网页判断某人心率、血压、胸闷、乏力或头晕一定由哪种药引起的工具。任何新症状、化验或监测异常都需要结合准确产品、病情和全部药单由专业人员判断。", "en": "“Alpha/beta blocking” is a mechanism pathway, not a web tool for deciding which medicine causes a person's heart rate, blood pressure, chest symptoms, fatigue or dizziness. Any new symptom, test or monitoring issue needs professional review with the exact product, condition and complete medicine list." }, { "zh": "与其他影响心率、传导、血压、血糖或体液状态的产品同用时，不能因为类别不同、都用于心血管问题或看起来不是同一种药就推定可以联用。尤其是地高辛、胺碘酮、某些钙通道阻滞剂、降压药、降糖药和非处方/补充剂都应带实际包装一起核对。", "en": "When another product affects heart rate, conduction, blood pressure, glucose or fluid status, a different class, shared cardiovascular use or a different-looking pack does not prove combination is safe. In particular, digoxin, amiodarone, certain calcium-channel blockers, blood-pressure medicines, glucose-lowering medicines and OTC/supplement products should be reviewed together with the actual packs." }, { "zh": "机制不能替代对缓释胶囊与普通片剂、不同强度、目标市场、既往反应和完整药单的逐项核对。考虑开始、停用、改量、换剂型、掰开药片或遇到新的明显不适时，应及时联系当地药师或医生。", "en": "Mechanism does not replace item-by-item checking of extended-release capsules versus regular tablets, different strengths, target market, prior reactions and the full medicine list. For a contemplated start, stop, adjustment, form change, tablet splitting or a new concerning symptom, contact a local pharmacist or clinician promptly." } ], "source": { "id": "src_7a6d051d5bf5e431", "label": "DailyMed（NLM）：COREG 卡维地洛当前美国公开标签（Waylis Therapeutics；Clinical Pharmacology）", "url": "https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=07c619c6-4a0c-445e-94fa-664a54f68a39", "audience": "public", "reviewStatus": "approved", "publish": true, "documentStatus": "current_regulatory_record", "documentKind": "product_label", "market": "US", "accessStatus": "public_access_confirmed", "accessMode": "public_web_page", "accessVerifiedAt": "2026-08-20", "reviewedAt": "2026-08-20" }, "scope": "mechanism_literacy_only_no_individual_dosing_or_substitution" }, "pharmacovigilance": { "status": "official_routes_only_no_live_alert_inference", "reviewedAt": "2026-08-22", "identity": { "brand": "Coreg", "generic": "卡维地洛", "dosageFormClass": "普通口服薄膜衣片：3.125 mg、6.25 mg、12.5 mg、25 mg；不与 COREG CR 缓释胶囊混同" }, "labelSource": { "id": "src_7a6d051d5bf5e431", "label": "DailyMed（NLM）：COREG 卡维地洛当前美国公开标签（Waylis Therapeutics；SPL v3，2026-08-03 发布）", "url": "https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=07c619c6-4a0c-445e-94fa-664a54f68a39", "audience": "public", "reviewStatus": "approved", "publish": true, "documentStatus": "current_regulatory_record", "documentKind": "product_label", "market": "US", "accessStatus": "public_access_confirmed", "accessMode": "public_web_page", "accessVerifiedAt": "2026-08-20", "reviewedAt": "2026-08-20" }, "productRoutes": [ { "source": { "id": "src_7a6d051d5bf5e431", "label": "DailyMed（NLM）：COREG 卡维地洛当前美国公开标签（Waylis Therapeutics；SPL v3，2026-08-03 发布）", "url": "https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=07c619c6-4a0c-445e-94fa-664a54f68a39", "audience": "public", "reviewStatus": "approved", "publish": true, "documentStatus": "current_regulatory_record", "documentKind": "product_label", "market": "US", "accessStatus": "public_access_confirmed", "accessMode": "public_web_page", "accessVerifiedAt": "2026-08-20", "reviewedAt": "2026-08-20" }, "status": "product_level_public_record_verified", "authority": { "zh": "美国国家医学图书馆 DailyMed", "en": "U.S. National Library of Medicine DailyMed" }, "market": { "zh": "美国", "en": "United States" }, "recordType": { "zh": "公开药品标签", "en": "Public medicine label" }, "reviewedAt": "2026-08-20", "scope": { "zh": "已逐项核对本档案可公开访问的产品级来源入口。该核对不代表已完成所有国家或地区的实时警示检索，也不代表该药存在或不存在当前风险。", "en": "This dossier’s publicly accessible product-level route has been checked individually. It does not mean that real-time alerts in every country or region have been searched, or that the medicine has or does not have a current risk." } } ], "recordRoute": { "status": "product_level_public_record_verified", "authority": { "zh": "美国国家医学图书馆 DailyMed", "en": "U.S. National Library of Medicine DailyMed" }, "market": { "zh": "美国", "en": "United States" }, "recordType": { "zh": "公开药品标签", "en": "Public medicine label" }, "reviewedAt": "2026-08-20", "scope": { "zh": "已逐项核对本档案可公开访问的产品级来源入口。该核对不代表已完成所有国家或地区的实时警示检索，也不代表该药存在或不存在当前风险。", "en": "This dossier’s publicly accessible product-level route has been checked individually. It does not mean that real-time alerts in every country or region have been searched, or that the medicine has or does not have a current risk." } }, "channels": [ { "id": "china-nmpa-drug-evaluation-centre", "authority": "NMPA 药品评价中心", "market": { "zh": "中国大陆", "en": "Mainland China" }, "title": { "zh": "药物警戒快讯与安全警示", "en": "Drug-vigilance bulletins and safety notices" }, "purpose": { "zh": "国家药监局药品评价中心发布的药物警戒快讯、安全警示及药品不良反应监测相关原始入口；具体产品仍须按批准文号、剂型、规格、持有人和公告日期逐项核对。", "en": "Primary NMPA Drug Evaluation Centre gateway for drug-vigilance bulletins, safety notices and adverse-reaction monitoring. Exact products still require checking approval number, dosage form, strength, authorisation holder and notice date item by item." }, "source": { "id": "src_05ff2860226564d4", "label": "国家药监局药品评价中心：药物警戒与安全警示入口", "url": "https://www.cdr-adr.org.cn/", "audience": "public", "reviewStatus": "approved", "publish": true, "documentStatus": "official_safety_monitoring", "documentKind": "regulatory_safety_communication", "market": "CN", "accessStatus": "public_access_confirmed", "accessMode": "public_web_page", "accessVerifiedAt": "2026-08-22", "reviewedAt": "2026-08-22" } }, { "id": "fda-drug-safety-communications", "authority": "FDA", "market": { "zh": "美国", "en": "United States" }, "title": { "zh": "药物安全通讯", "en": "Drug Safety Communications" }, "purpose": { "zh": "监管机构就重要新安全问题、标签变化或风险沟通发布的原始页面。", "en": "Primary FDA pages for important new safety issues, labelling changes and risk communications." }, "source": { "id": "src_9177df9e1825aa72", "label": "FDA：Drug Safety Communications", "url": "https://www.fda.gov/drugs/drug-safety-and-availability/drug-safety-communications", "audience": "public", "reviewStatus": "approved", "publish": true, "documentStatus": "official_safety_monitoring", "documentKind": "regulatory_safety_communication", "market": "US", "accessStatus": "public_access_confirmed", "accessMode": "public_web_page", "accessVerifiedAt": "2026-08-22", "reviewedAt": "2026-08-22" } }, { "id": "fda-medwatch", "authority": "FDA MedWatch", "market": { "zh": "美国", "en": "United States" }, "title": { "zh": "安全信息与严重问题报告", "en": "Safety information and serious-problem reporting" }, "purpose": { "zh": "美国 MedWatch 的安全信息和报告入口；报告不等同于已证实因果关系。", "en": "U.S. MedWatch safety-information and reporting gateway; a report does not itself establish causality." }, "source": { "id": "src_e4739cd55d27ab51", "label": "FDA：MedWatch 药品安全信息与不良事件报告计划", "url": "https://www.fda.gov/safety/medwatch-fda-safety-information-and-adverse-event-reporting-program", "audience": "public", "reviewStatus": "approved", "publish": true, "documentStatus": "official_safety_monitoring", "documentKind": "adverse_event_reporting", "market": "US", "accessStatus": "public_access_confirmed", "accessMode": "public_web_page", "accessVerifiedAt": "2026-08-22", "reviewedAt": "2026-08-22" } }, { "id": "ema-pharmacovigilance", "authority": "EMA", "market": { "zh": "欧盟/欧洲经济区", "en": "European Union / European Economic Area" }, "title": { "zh": "药物警戒概览与 EudraVigilance", "en": "Pharmacovigilance overview and EudraVigilance" }, "purpose": { "zh": "欧盟药物警戒、疑似不良反应报告和 PRAC 安全评估的官方入口。", "en": "Official EU gateway for pharmacovigilance, suspected adverse-reaction reports and PRAC safety assessment." }, "source": { "id": "src_2ad42a3deae747d1", "label": "EMA：Pharmacovigilance overview", "url": "https://www.ema.europa.eu/en/human-regulatory-overview/pharmacovigilance-overview", "audience": "public", "reviewStatus": "approved", "publish": true, "documentStatus": "official_safety_monitoring", "documentKind": "regulatory_safety_communication", "market": "EU", "accessStatus": "public_access_confirmed", "accessMode": "javascript_or_cookie_controls", "accessVerifiedAt": "2026-08-22", "reviewedAt": "2026-08-22" } }, { "id": "mhra-drug-safety-update", "authority": "MHRA", "market": { "zh": "英国", "en": "United Kingdom" }, "title": { "zh": "Drug Safety Update", "en": "Drug Safety Update" }, "purpose": { "zh": "英国 MHRA 面向专业人士和公众的药品安全更新原始发布页。", "en": "Primary UK MHRA medicine-safety updates for professionals and the public." }, "source": { "id": "src_23fdbe67abeafc63", "label": "MHRA：Drug Safety Update", "url": "https://www.gov.uk/drug-safety-update", "audience": "public", "reviewStatus": "approved", "publish": true, "documentStatus": "official_safety_monitoring", "documentKind": "regulatory_safety_communication", "market": "UK", "accessStatus": "public_access_confirmed", "accessMode": "public_web_page", "accessVerifiedAt": "2026-08-22", "reviewedAt": "2026-08-22" } }, { "id": "pmda-drug-safety", "authority": "PMDA", "market": { "zh": "日本", "en": "Japan" }, "title": { "zh": "药品安全信息", "en": "Medicine safety information" }, "purpose": { "zh": "日本 PMDA 药品安全信息的英文官方入口；具体产品仍应以日文产品页和现行文件复核。", "en": "PMDA’s English official safety gateway; exact products still require checking against the Japanese product page and current documents." }, "source": { "id": "src_06d6be2880f12024", "label": "PMDA：Safety Information Regarding Drugs", "url": "https://www.pmda.go.jp/english/safety/info-services/drugs/0001.html", "audience": "public", "reviewStatus": "approved", "publish": true, "documentStatus": "official_safety_monitoring", "documentKind": "regulatory_safety_communication", "market": "JP", "accessStatus": "public_access_confirmed", "accessMode": "public_web_page", "accessVerifiedAt": "2026-08-22", "reviewedAt": "2026-08-22" } }, { "id": "mfds-drug-safety-letters", "authority": "MFDS", "market": { "zh": "韩国", "en": "Republic of Korea" }, "title": { "zh": "药品安全性书信", "en": "Medicine safety letters" }, "purpose": { "zh": "韩国 MFDS 发布的药品安全性书信原始索引。原文为韩文，须按涉及产品、剂型、市场和日期逐项阅读；它不自动适用于其他市场，也不构成对个人情况的结论。", "en": "MFDS’s primary index for medicine safety letters in the Republic of Korea. The original notices are in Korean and must be read against the named product, dosage form, market and date; they do not automatically apply in another market or decide an individual case." }, "source": { "id": "src_2d7f5018cd05eff4", "label": "MFDS：药品安全性书信（韩文原始资料）", "url": "https://www.mfds.go.kr/brd/m_545/list.do", "audience": "public", "reviewStatus": "approved", "publish": true, "documentStatus": "official_safety_monitoring", "documentKind": "regulatory_safety_communication", "market": "KR", "accessStatus": "public_access_confirmed", "accessMode": "public_web_page", "accessVerifiedAt": "2026-08-22", "reviewedAt": "2026-08-22" } }, { "id": "hsa-adverse-events", "authority": "HSA", "market": { "zh": "新加坡", "en": "Singapore" }, "title": { "zh": "不良反应报告与药物安全信息", "en": "Adverse-event reporting and medicine-safety information" }, "purpose": { "zh": "新加坡 HSA 面向公众的疑似不良反应报告、药物安全信息与本地监管入口；一份报告不等同于个体因果关系，具体产品仍须按新加坡注册状态、剂型、规格、日期和现行产品资料逐项核对。", "en": "HSA’s public Singapore gateway for suspected adverse-event reporting and medicine-safety information. A report does not itself establish individual causality; exact products still require checking Singapore registration status, dosage form, strength, date and current product information." }, "source": { "id": "src_9240397d5a8574c1", "label": "HSA：Report adverse events", "url": "https://www.hsa.gov.sg/adverse-events/", "audience": "public", "reviewStatus": "approved", "publish": true, "documentStatus": "official_safety_monitoring", "documentKind": "adverse_event_reporting", "market": "SG", "accessStatus": "public_access_confirmed", "accessMode": "public_web_page", "accessVerifiedAt": "2026-08-22", "reviewedAt": "2026-08-22" } }, { "id": "health-canada-medeffect-advisories", "authority": "Health Canada", "market": { "zh": "加拿大", "en": "Canada" }, "title": { "zh": "MedEffect 加拿大：建议、警告与召回", "en": "MedEffect Canada: advisories, warnings and recalls" }, "purpose": { "zh": "加拿大政府 Health Canada 的 MedEffect 公开入口，汇集药品及健康产品的建议、警告、召回、报告与安全信息；具体产品仍须按市场、剂型、规格、公告日期和批号逐项核对。", "en": "Health Canada’s public MedEffect gateway for medicine and health-product advisories, warnings, recalls, reporting and safety information. Exact products still require checking market, dosage form, strength, notice date and lot item by item." }, "source": { "id": "src_212ec921fa6634ad", "label": "Health Canada：MedEffect Canada 建议、警告与召回", "url": "https://www.canada.ca/en/health-canada/services/drugs-health-products/medeffect-canada/advisories-warnings-recalls.html", "audience": "public", "reviewStatus": "approved", "publish": true, "documentStatus": "official_safety_monitoring", "documentKind": "regulatory_safety_communication", "market": "CA", "accessStatus": "public_access_confirmed", "accessMode": "public_web_page", "accessVerifiedAt": "2026-08-22", "reviewedAt": "2026-08-22" } }, { "id": "tga-safety-alerts", "authority": "TGA", "market": { "zh": "澳大利亚", "en": "Australia" }, "title": { "zh": "药品安全警示", "en": "Medicine safety alerts" }, "purpose": { "zh": "澳大利亚 TGA 的药品安全警示、建议和监测信息原始发布页。", "en": "Primary Australian TGA safety alerts, advisories and monitoring information for therapeutic products." }, "source": { "id": "src_ffe6142814f88fac", "label": "TGA：Safety alerts", "url": "https://www.tga.gov.au/safety/safety-monitoring-and-information/safety-alerts", "audience": "public", "reviewStatus": "approved", "publish": true, "documentStatus": "official_safety_monitoring", "documentKind": "regulatory_safety_communication", "market": "AU", "accessStatus": "public_access_confirmed", "accessMode": "public_web_page", "accessVerifiedAt": "2026-08-22", "reviewedAt": "2026-08-22" } }, { "id": "swissmedic-pharmacovigilance", "authority": "Swissmedic", "market": { "zh": "瑞士", "en": "Switzerland" }, "title": { "zh": "药物警戒与不良反应报告", "en": "Pharmacovigilance and suspected adverse-reaction reporting" }, "purpose": { "zh": "瑞士 Swissmedic 的药物警戒、信号评估和疑似不良反应官方入口；报告或信号本身不等同于对个体因果关系的确认。", "en": "Official Swissmedic gateway for pharmacovigilance, signal assessment and suspected adverse-reaction reporting; a report or signal does not itself confirm individual causality." }, "source": { "id": "src_c854f813ce2671df", "label": "Swissmedic：Pharmacovigilance", "url": "https://www.swissmedic.ch/swissmedic/en/home/humanarzneimittel/market-surveillance/pharmacovigilance.html", "audience": "public", "reviewStatus": "approved", "publish": true, "documentStatus": "official_safety_monitoring", "documentKind": "adverse_event_reporting", "market": "CH", "accessStatus": "public_access_confirmed", "accessMode": "public_web_page", "accessVerifiedAt": "2026-08-22", "reviewedAt": "2026-08-22" } }, { "id": "medsafe-safety-communications", "authority": "Medsafe", "market": { "zh": "新西兰", "en": "New Zealand" }, "title": { "zh": "药品安全通讯", "en": "Medicine safety communications" }, "purpose": { "zh": "新西兰 Medsafe 面向公众和专业人士的药品安全通讯与归档入口；旧公告可能已被现行产品资料更新。", "en": "New Zealand Medsafe gateway for public and professional medicine safety communications and archives; older notices may have been superseded by current product information." }, "source": { "id": "src_3510c1a523ec9769", "label": "Medsafe：Safety Communications", "url": "https://www.medsafe.govt.nz/safety/SafetyCommunications.asp", "audience": "public", "reviewStatus": "approved", "publish": true, "documentStatus": "official_safety_monitoring", "documentKind": "regulatory_safety_communication", "market": "NZ", "accessStatus": "public_access_confirmed", "accessMode": "public_web_page", "accessVerifiedAt": "2026-08-22", "reviewedAt": "2026-08-22" } }, { "id": "sahpra-safety-information", "authority": "SAHPRA", "market": { "zh": "南非", "en": "South Africa" }, "title": { "zh": "药物安全信息、警示与药物警戒", "en": "Medicine safety information, alerts and pharmacovigilance" }, "purpose": { "zh": "南非 SAHPRA 面向公众和专业人士的药物安全信息、警示与药物警戒入口；官方警示不等同于产品在所有情形下不安全，具体产品仍须按南非注册状态、剂型、规格、公告日期与现行资料逐项核对。", "en": "SAHPRA’s safety-information, alerts and pharmacovigilance gateway for the public and professionals in South Africa. An official alert does not itself mean a product is unsafe in every circumstance; exact products still require checking South African registration status, dosage form, strength, notice date and current product information." }, "source": { "id": "src_25b0aaefee742163", "label": "SAHPRA：Safety Information Updates / Pharmacovigilance", "url": "https://www.sahpra.org.za/safety-information-and-updates/", "audience": "public", "reviewStatus": "approved", "publish": true, "documentStatus": "official_safety_monitoring", "documentKind": "regulatory_safety_communication", "market": "ZA", "accessStatus": "public_access_confirmed", "accessMode": "public_web_page", "accessVerifiedAt": "2026-08-22", "reviewedAt": "2026-08-22" } }, { "id": "who-medicine-safety-alerts", "authority": "WHO", "market": { "zh": "全球", "en": "Global" }, "title": { "zh": "药品与疫苗安全警示档案", "en": "Medicine and vaccine safety-alert archive" }, "purpose": { "zh": "WHO 的跨市场安全警示档案；每条历史警示必须按公告日期、涉及产品和市场单独阅读。", "en": "WHO’s cross-market safety-alert archive; every historical notice must be read against its date, named product and market." }, "source": { "id": "src_9a7dc56ec34c7e1a", "label": "WHO：Safety alerts for medicines and vaccines", "url": "https://www.who.int/teams/regulation-prequalification/regulation-and-safety/pharmacovigilance/safety-alerts", "audience": "public", "reviewStatus": "approved", "publish": true, "documentStatus": "official_safety_monitoring", "documentKind": "regulatory_safety_communication", "market": "GLOBAL", "accessStatus": "public_access_confirmed", "accessMode": "public_web_page", "accessVerifiedAt": "2026-08-22", "reviewedAt": "2026-08-22" } }, { "id": "anvisa-pharmacovigilance", "authority": "Anvisa", "market": { "zh": "巴西", "en": "Brazil" }, "title": { "zh": "药物警戒、警示与 VigiMed", "en": "Pharmacovigilance, alerts and VigiMed" }, "purpose": { "zh": "巴西 Anvisa 的药物警戒原始入口，涵盖警示、药物警戒公告、风险沟通和 VigiMed 报告路径；具体产品仍须按巴西批准状态、剂型、规格和公告日期逐项核对。", "en": "Anvisa’s primary Brazilian pharmacovigilance gateway for alerts, bulletins, risk communication and VigiMed reporting. Exact products still require checking Brazilian authorisation status, dosage form, strength and notice date item by item." }, "source": { "id": "src_5de362c12580111d", "label": "Anvisa：Farmacovigilância（药物警戒、警示与 VigiMed）", "url": "https://www.gov.br/anvisa/pt-br/assuntos/fiscalizacao-e-monitoramento/farmacovigilancia", "audience": "public", "reviewStatus": "approved", "publish": true, "documentStatus": "official_safety_monitoring", "documentKind": "regulatory_safety_communication", "market": "BR", "accessStatus": "public_access_confirmed", "accessMode": "public_web_page", "accessVerifiedAt": "2026-08-22", "reviewedAt": "2026-08-22" } } ], "notices": [], "boundary": { "zh": "本卡将逐药产品级来源与 15 个市场级官方警戒入口放在同一处核验；它不表示已完成该药在所有国家或地区的实时警示检索，也不表示该药存在新的安全警示、召回或风险结论。请先以品牌名、通用名、剂型、规格、所在市场和公告日期逐项匹配；不要仅因看到标题自行停药、换药、加量或减量。", "en": "This card brings together the medicine-specific product route and 15 market-level official vigilance gateways. It does not mean real-time alerts for this medicine have been searched in every country or region, or that the medicine has a new alert, recall or risk conclusion. Match brand, generic name, dosage form, strength, market and notice date item by item; do not self-stop, switch, increase or reduce use from a headline." }, "scope": "official_routes_only_no_live_alert_inference" }, "archive": { "summary": "美国 DailyMed 的当前 COREG（carvedilol）标签列示 3.125、6.25、12.5、25 mg 四种普通口服薄膜衣片。本页逐项展示四个 100 片瓶装面板，帮助核对品牌、通用名、每片标示量、NDC、普通片剂与来源；不把包装上的毫克数转成个人片数、加减量、掰开、补用、停用、联用或换药方案。", "history": "COREG 普通片与 COREG CR 缓释胶囊不是同一剂型或同一产品身份。商品名中都有“Coreg”、通用名相近或数字看起来可对应，都不能建立毫克对毫克换算、合用、轮换或替换关系。", "sourceDocuments": [ { "id": "src_7a6d051d5bf5e431", "label": "DailyMed（NLM）：COREG 卡维地洛当前美国公开标签（Waylis Therapeutics；SPL v3，2026-08-03 发布）", "url": "https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=07c619c6-4a0c-445e-94fa-664a54f68a39", "audience": "public", "reviewStatus": "approved", "publish": true, "documentStatus": "current_regulatory_record", "documentKind": "product_label", "market": "US", "accessStatus": "public_access_confirmed", "accessMode": "public_web_page", "accessVerifiedAt": "2026-08-20", "reviewedAt": "2026-08-20" }, { "id": "src_952c673477e77d40", "label": "FDA：COREG（carvedilol）NDA 020297 历史批准资料", "url": "https://www.accessdata.fda.gov/drugsatfda_docs/nda/99/20297s4_Coreg.pdf", "audience": "public", "reviewStatus": "approved", "publish": true, "documentStatus": "historical_public_record", "documentKind": "approval_history", "market": "US", "accessStatus": "public_access_confirmed", "accessMode": "direct_document", "accessVerifiedAt": "2026-08-20", "reviewedAt": "2026-08-20" }, { "id": "src_5ed30b676fbb9773", "label": "FDA Drugs@FDA 官方检索入口", "url": "https://www.accessdata.fda.gov/scripts/cder/daf/", "audience": "public", "reviewStatus": "approved", "publish": true, "documentStatus": "official_lookup_entry", "documentKind": "regulatory_lookup", "market": "US", "accessStatus": "public_access_requires_interaction", "accessMode": "interactive_lookup", "accessVerifiedAt": "2026-08-20", "reviewedAt": "2026-08-20" } ], "applicationNumber": "NDA 020297", "approvalTimeline": [ { "date": "1995", "title": { "zh": "当前标签所列美国初始批准年份", "en": "Initial U.S. approval year listed in the current label" }, "detail": { "zh": "当前 COREG 标签列示 Initial U.S. Approval: 1995。这个年份只定位本页所链接的美国标签和历史申请资料，不建立中国大陆、欧盟、日本或其他市场的批准、持有人、供应、可售资格、原研/仿制关系或个人适用性。", "en": "The current COREG label lists Initial U.S. Approval: 1995. This year only locates the U.S. label and historical application material linked on this page; it does not establish approval, holder, supply, sale eligibility, originator/generic relationship or individual suitability in Mainland China, the EU, Japan or another market." }, "source": { "id": "src_7a6d051d5bf5e431", "label": "DailyMed（NLM）：COREG 卡维地洛当前美国公开标签（Waylis Therapeutics；SPL v3，2026-08-03 发布）", "url": "https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=07c619c6-4a0c-445e-94fa-664a54f68a39", "audience": "public", "reviewStatus": "approved", "publish": true, "documentStatus": "current_regulatory_record", "documentKind": "product_label", "market": "US", "accessStatus": "public_access_confirmed", "accessMode": "public_web_page", "accessVerifiedAt": "2026-08-20", "reviewedAt": "2026-08-20" } }, { "date": "2026-08-03", "title": { "zh": "当前 DailyMed SPL v3 公开", "en": "Current DailyMed SPL v3 published" }, "detail": { "zh": "DailyMed 媒体目录列示 COREG 当前 SPL v3 于 2026-08-03 发布；页面更新日期为 2026-07-31。本页分别展示四个准确 100 片瓶装面板，不据此建立实际库存、购买、个人片数、COREG CR 转换或其他市场状态。", "en": "The DailyMed media catalogue lists current COREG SPL v3 as published on 3 Aug 2026; the page update date is 31 Jul 2026. This page separately displays four exact 100-tablet bottle panels and does not establish actual stock, purchase, individual tablet count, conversion to COREG CR or another-market status." }, "source": { "id": "src_7a6d051d5bf5e431", "label": "DailyMed（NLM）：COREG 卡维地洛当前美国公开标签（Waylis Therapeutics；SPL v3，2026-08-03 发布）", "url": "https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=07c619c6-4a0c-445e-94fa-664a54f68a39", "audience": "public", "reviewStatus": "approved", "publish": true, "documentStatus": "current_regulatory_record", "documentKind": "product_label", "market": "US", "accessStatus": "public_access_confirmed", "accessMode": "public_web_page", "accessVerifiedAt": "2026-08-20", "reviewedAt": "2026-08-20" } } ], "marketStatus": [ { "market": { "zh": "美国", "en": "United States" }, "status": { "zh": "已链接当前公开标签与四个准确 100 片瓶装面板", "en": "Current public label and four exact 100-tablet bottle panels linked" }, "detail": { "zh": "本页面板分别对应 NDC 80725-139-20（3.125 mg）、80725-140-20（6.25 mg）、80725-141-20（12.5 mg）和 80725-142-20（25 mg）。它们不用于鉴定真伪，也不建立实际在售、库存、购买、个人片数、掰开、停用、联用或可替代性。", "en": "The panels correspond respectively to NDC 80725-139-20 (3.125 mg), 80725-140-20 (6.25 mg), 80725-141-20 (12.5 mg) and 80725-142-20 (25 mg). They do not authenticate a product or establish actual availability, stock, purchase, individual tablet count, splitting, discontinuation, co-use or interchangeability." } }, { "market": { "zh": "中国大陆、欧盟、日本及其他市场", "en": "Mainland China, EU, Japan and other markets" }, "status": { "zh": "待逐项建立市场记录", "en": "Market record not established" }, "detail": { "zh": "不从美国标签、NDC 或品牌名称推定当地商品名、批准、包装、供应、可售资格、原研/仿制关系或可替代性；每个市场都需按当地现行监管资料单独核对。", "en": "No local trade name, approval, packaging, supply, sale eligibility, originator/generic relationship or interchangeability is inferred from the U.S. label, NDC or brand name; every market needs separate checking against current local regulatory information." } } ], "frequentlyAskedQuestions": [ { "question": { "zh": "COREG 普通片与 COREG CR 缓释胶囊能否按毫克数或服用频率自行换算？", "en": "Can regular COREG tablets and COREG CR extended-release capsules be self-converted by milligrams or dosing frequency?" }, "answer": { "zh": "不能。本页普通片的品牌、通用名、毫克数、NDC 和包装信息只能用于核对准确产品身份。缓释胶囊有不同剂型和标签层面；不要凭相同品牌、相近数字或照片自行换算、替换、叠加或停用。请带两种实际药盒、处方和完整药单请药师或开方团队核对。", "en": "No. The brand, generic name, milligrams, NDC and package information for the regular tablets on this page only help identify the exact product. The extended-release capsule is a different dosage-form and label layer; do not self-convert, substitute, combine or stop based on a shared brand, similar numbers or a photo. Take both actual packs, the prescription and complete medicine list to a pharmacist or prescriber for review." } } ], "relatedMedicineChecks": [ { "target": { "id": "lanoxin", "brand": "Lanoxin", "generic": "地高辛", "canonicalUrls": { "zh": "https://origindrug.com/drugs/lanoxin/", "en": "https://origindrug.com/en/drugs/lanoxin/" } }, "title": { "zh": "与 LANOXIN／地高辛同在药单上时：先做完整药单核对", "en": "When LANOXIN / digoxin is on the same list: review the complete medicine list first" }, "summary": { "zh": "COREG 的当前美国公开标签将地高辛列为需要核对的联用线索，并提示两者都可能影响房室传导和心率。这张卡只提示将全部实际药盒、非处方药、补充剂与近期症状带给药师或开方团队复核；它不判断能否同服，不建议自行停用、错开时间、替换或调整任何一种药。", "en": "The current U.S. COREG public label names digoxin as a co-medication cue requiring review and notes that both can affect atrioventricular conduction and heart rate. This card only signals that every actual pack, OTC product, supplement and recent symptom should be reviewed by a pharmacist or prescriber; it does not decide co-use or advise self-stopping, time-separation, replacement or adjustment of either medicine." }, "source": { "id": "src_7a6d051d5bf5e431", "label": "DailyMed（NLM）：COREG 卡维地洛当前美国公开标签（Waylis Therapeutics；Warnings, Interactions and Patient Counseling）", "url": "https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=07c619c6-4a0c-445e-94fa-664a54f68a39", "audience": "public", "reviewStatus": "approved", "publish": true, "documentStatus": "current_regulatory_record", "documentKind": "product_label", "market": "US", "accessStatus": "public_access_confirmed", "accessMode": "public_web_page", "accessVerifiedAt": "2026-08-20", "reviewedAt": "2026-08-20" }, "scope": "review_complete_medicine_list_no_self_directed_change" } ], "relatedArticleSlugs": [] }, "canonicalUrls": { "zh": "https://origindrug.com/drugs/coreg/", "en": "https://origindrug.com/en/drugs/coreg/" }, "limitations": [ "No originator, generic, interchangeability, availability, price, holder, strength or sale-eligibility conclusion is inferred beyond the linked source documents.", "Target-market current labels and official records must be checked separately." ] }