Medicine pack check sheet

Source-linked reading points

• Start with ‘prolonged/extended release’: do not crush, break or chew. An unscored tablet is not permission to split by feel, and a shared mg figure across markets does not permit assembling one market's larger strength from another's smaller tablets.
• RANEXA is a chronic stable-angina dossier, not a rescue substitute for sublingual nitroglycerin such as NITROSTAT. New, different, severe or persistent chest pain, or pain with breathing difficulty, sweating or fainting, requires immediate local emergency care; do not wait for a website or self-add a tablet.
• Strong CYP3A inhibitors such as clarithromycin, ketoconazole, itraconazole, voriconazole and some HIV protease inhibitors, and inducers such as rifampin, carbamazepine, phenytoin, phenobarbital and St John's wort, are priority review items. Do not try to solve them by self-separating doses by a few hours.
• Diltiazem, verapamil, fluconazole, erythromycin, ciclosporin and grapefruit can affect ranolazine exposure; digoxin, simvastatin, metformin and other medicines may also need joint review. This site does not decide co-use or dose reduction from two names.